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Botanical
Pueraria Mirifica Research
Botanical Pueraria Mirifica Herb
Research
( Scientific Name:
Pueraria Mirifica A Shaw et Suvatabhandu
)
Our researcher has started research on
Pueraria mirifica since 1991 and then later on Butea superba.
Pueraria mirifica (White Kwao Krua) is Thailand’s endemic
species found mainly in the northern and western part of
Thailand and has local name as “White Kwao Krua”. The Thai
vine herbal plant is grown in association with the
moderate-size trees ranking from timber wood to bamboo in the
deciduous rain forest.
Botanical Pueraria Mirifica’s Study
The
enlarge underground tuber accumulate “ phytoestrogens ”
(Hormone from Plant) comprising isoflavones (daidzin,
daidzein, genistin, genistein and puerarin) and others such as
"miroestrol" & "deoxymiroestol"
- "The best & unique phytoestrogens in the world ever found by
mankind" and its derivatives, beta-sitosterol, stigmasterol,
coumestrol, puerarin, mirificoumestan, kwakhurin and
mirificin.
The scope of our study is biotechnology of the White ,
Red and Black Kwao Krua. Our study has be done by traveling to
many forests in many parts of Thailand to search and select
for the right and best cultivar of these herbs by rely on
botanical characteristic, chemical analysis, consumption
history, toxicology test as well as laboratory test and
clinical trial.
The result of study under controlled by
researcher
According to our research has revealed
that Pueraria Mirifica and
Butea Superba are safe to be
used in human in certain dosage as well as consumption
period.
More than 20 kinds of chemical
substances were analyzed from Pueraria Mirifica and they were divided
in to 3 groups
1. A mild action substances in the group
of Sterol.
2. The substances in Isoflavanoid groups
which also be found in soybean, a commonly used health
nourishment in Japanese food and is proven to be anti-breast
cancer.
3. An acute substances of Coumestan
group
Our researcher has been conducting a
series of researches covering the chemical analysis, tissue
culture, mass propagation, cultivar improvement, production,
product development and testing and so on for 9 years. Because
this finding showed a great impact to the herbal food,
cosmetic, drug and beverage industries, so he has submitted
patents concerned these findings and application in both
Thailand and abroad
The result shows that our selected Pueraria Mirifica
cultivar contains very high isoflavone contents and showing
high antimutagenic effects as well as high killing effects to
human mammary cancer cell line.
Nowadays nutritionists recommend the consumer to
consume isoflavone regularly for the purpose of cancer
protection normally found on post-menopausal and people who
are Hormone Imbalance.
What is benefit of Miroestrol and its
derivatives?
Miroestrol and its derivatives are
also precious chemicals in the White Kwao Krua which promote
estrogenic and mammogenic effects to various tissues as Breast
Enlargement or Breast Tissue Reformation.
( See the result
of Clinical study about Breast Enlargement by Pueraria mirifca
herbal and FAQ Breast Enlargement Forum ) and organs such as
uterus, ovary and skin as HRT (Hormone Replacement
Therapy)
What is different between Soya and Pueraria
Mirifica ?
Soya, the main oriental food and
Alfalfa, the western health food products contains lower
amount of phytoestrogens especially there is no miroestrol and
its derivatives. Their benefit to the body is far less than
that of Pueraria mirifica. The researches confirm that these
chemicals are potent anti-breast cancer ,
anti-prostate hyperplasia, anti-colon cancer,
anti-osteoporosis and also
anti-cardiovascular disease via the potent reduction of blood
cholesterol and also anti-menopausal
syndrome.
Further information about : Chemical Composition and
Hormone Replacement Therapy
Published by : Medicinal Plant
Research Institute, Department of Medical Sciences, Ministry
of Public Health, Thailand , July 2000
-
Efficacy and safety
of Pueraria mirifica (Kwao Kruea Khao) for the
treatment of vasomotor symptoms in pre-menopausal
women: Phase II Study.
J Med Assoc Thai. 2004
Jan;87(1):33-40. Lamlertkittikul
S, Chandeying V.
Department of
Obstetrics and Gynecology, Hat Yai Regional
Hospital, Songkhla 90110, Thailand.
OBJECTIVES:
To evaluate the preliminary efficacy and safety of
Pueraria mirifica in the treatment of vasomotor
symptoms. DESIGN: Open-label study. SETTING: Hat Yai
Regional Hospital, Thailand. SUBJECTS: Pre and
postmenopausal women with vasomotor symptoms, such
as hot flushes and night sweats. Other unpleasant
symptoms, urogenital and psychological symptoms,
were also evaluated.
MATERIAL AND METHOD:
Patients were enrolled voluntarily and randomly
received 50 mg or 100 mg of Pueraria mirifica in
capsules, once daily for six months.
RESULTS: Of
the 48 enrolled patients, 11 cases were excluded for
failing to complete the initial work-up.
Thirty-seven cases were evaluated. 20 of 37 (54.1%)
randomly received a dose of 50 mg/day of Pueraria
mirifica (Group A), and 17 of 37 (45.9%) received
100 mg/day of Pueraria mirifica (Group B). The mean
of the modified Greene climacteric scale decreased
from 35.6 to 26.6, 17.2 and 15.1 in group A, while
group B, declined from 32.6 to 21.0, 14.8 and 13.6
at 1-, 3- and 6-month respectively. The mean serum
estradiol, fluctuated from the baseline of 76.6 to
55.4, 56.7, 72.5, 69.2, 114.2 and 74.5 pg/ml at 1-,
2-, 3-, 4-, 5- and 6-month respectively. Whereas the
mean serum follicle-stimulating hormone (FSH)/luteinizing
hormone (LH) was stable in the range of; 27.1/12.6,
28.3/12.9and 22.5/11.4 mIU/ml at baseline, 3- and
6-month respectively.
CONCLUSIONS:
Pueraria mirifica, containing
phytoestrogens, relatively alleviated the
climacteric symptoms in perimenopausal women. The
transient negative profiles occurred in a small
number of subjects that included anemia, and liver
profiles. While there was a slight decrease in
lipoproteins and an increase in hormonal profiles,
Pueraria mirifica demonstrates great promise in the
treatment of climacteric symptoms among
perimenopausal women. However, optimal doses should
be clinically assessed, to meet appropriate
individual responses.
-
-
Chulalongkorn
University
Conclusion of
Clinical Study (pre-menopausal women)
Pre-menopausal women
Function: (Food Supplement)
Test Period: 2 months
Number of subjects: 31 Placebo
test group 1. 2 200 mg capsule/ day 15 days/month
test group 2 4 200 mg capsules 15
days/month
This test group showed significant change with
different number in all recorded parameters,
including, including mammary pain (44%) which is
related to breast firmness and may relate to breast
enlargement, nicer skin(88%), healthier
hair(75%),charisma clearance(100%), increase vaginal
secretion(44%),breast enlargement(90%), and hip
enlargement(9%).
The second tested group contains 34 subjects,
received 200 mg Pueraria mirifica filled capsule to
consume 4 capsules/day in the same condition as the
placebo group. This group showed significant change
with higher numbers in all recorded parameters,
including mammary pain (94%), skin recovery (94%),
healthier hair (88%), charisma clearance (100%),
increased vaginal secretion (85%), and thus could
restore female potency in some subjects, healthier
menstruation, (29%), breast firmness (94%), breast
enlargement (88%), and hip enlargement (59%). Some
subjects claimed that the high blood cholesterol
levels also decreased.
Conclusion : Pueraria Mirifica enhanced breast size
and firmness
source: Copyright © 2002 [Americanphytolab.netfirms].
All rights reserved. Revised: 02/09//2005 |
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Pueraria
Mirifica contains different types of Phytoestrogens, which
may be broadly classified into thress main groups:
1. Chromene group
: The Miroestrol and Deoxymiroestrol, these are comparatively
potent Phytoestrogens Unique to Pueraria Mirifica, their
structural configuration is very close to the structural
configuration of Estradiol-17B.
2. Isoflavonoid
group : which comprises of Daidzin and Daidzein, Genistin and
Genistein, also Puerarin.
3. The Coumestan
group comprising cousmetrol.
This wide variety
of Pytoestrogenic compounds belonging to different
groups and present side by side in a single plant, is what make
Pueraria Mirifica a very appreciated herb for replacing
the decline in the natural hormones in women over 45 years of
age or insufficient of estrogen below 45 years age.
Taking estrogenic
hormones (synthetic hormones), has been proven to be
carcinogenic. On the other hand, taking Phytoestrogens proved to
be anti-carcinogenic or at least delay carcinogenic
manifestations. A considerable amount of data has accumulated
proving that Phytoestrogens exhibits an inhibitory effect
against mammary tumorigenesis, prostate-related cancer and
bladder cancer.
Phytoestrogens
also exhibit favorable effects other than the dramatic results
of protection against certain types of cancer. In other words,
as result of the decrease in the level of estrogenic hormones,
the body's systems and their function begin to decelerate and
the immune system weakens, accordingly menopausal women will
usually experience both psychological and physiological changes.
Psychological changes ranges from anxiety, tension and
nervousness to chronic depression, whereas the physiological
changes include hot flushes, fatigue and insomnia to more severe
conditions as bone loss, balding and degeneration of the
reproductive area.
The health
benefits of Phytoestrogens from Pueraria Mirifica is at least 2
folds:
First they can
bind to the estrogen receptors with respective degrees of
affinity. Hence unique phytoestrogens from Pueraria Mirifica can
correct estrogen insufficient in the body and relieve any
resulting symptoms.
Secondly, there
is evidence to support that phytoestrogen consumption
contributes to lower risks of cardiovascular diseases. Soy bean,
which contains similar isoflavonoids as those found in Pueraria
Mirifica, was proven to decrease the level of LDL, Cholestrol
and increase the level of HDL in the blood.
The following
safety Studies were conducted:
Mutagenicity
Assay: Ames test showed no sign of Mutagenicity for Pueraria
Mirifica.
LD-50: The LD-50
of Pueraria Mirifica in mice was found to be greater than 16g/kg
of the body weight. Since the normal therapeutic dose has been
estimated to be 0.8-1.3 mg/kg/day, it is quite obvious that the
safety margin is very high. [ Chivapat, S., Chavalittumrong, P.,
Rattanajarasroj, S., Chuthaputti, A. and Panyamang, S., Bull.
Dept, Med, Sciences, 42, 202 (2000) ]
Human Studies:
Three female human studies, two in Thailand and one in Japan,
were conducted, no significant signs of toxicity or adverse
effects could be reported by the investigators. [ Chandeying,
V., Kuramoshi, T. and Schauss, A., Personal Communication (2001)
]
Skin Tests: With
regards to the safety and efficacy of dermal preparations of
Pueraria Mirifica extract, standard dermal toxicity tests were
performed in various animal species as well as in human and no
toxicity was observed. Moreover, the efficacy of breast creams
has been recently evaluated in a large group of human volanteers.
[ Thailand Institute of Scientific and Technological Research
(July 2002) ]
Various forms and
preparations of Pueraria Mirifica should provide an effective,
safe and inexpensive alternative to women who wish to take
charge of their own health and to enhance their beauty or
utilize Pueraria Mirifica for various cosmetic purposes.
When applied to the
skin Pueraria Mirifica will be beneficial to that respective
part of the body. Topical uses of Pueraria Mirifica have been
known to include:
Breast Creams, Breast Spray, Breast Serum, Breast Mask
CLICK HERE!
Eye gel,
Facial Day Cream, Facial Night Cream, Facial Mask
CLICK HERE!
Woman Factor
plus
CLICK
HERE!
 
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