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Botanical Pueraria Mirifica  Research       Buy Woman Factor plus now at Pharmacy in Malaysia!

 

 
Botanical Pueraria Mirifica Herb Research
( Scientific Name: Pueraria Mirifica A Shaw et Suvatabhandu )
Our researcher has started research on Pueraria mirifica since 1991 and then later on Butea superba. Pueraria mirifica (White Kwao Krua) is Thailand’s endemic species found mainly in the northern and western part of Thailand and has local name as “White Kwao Krua”. The Thai vine herbal plant is grown in association with the moderate-size trees ranking from timber wood to bamboo in the deciduous rain forest.

Botanical Pueraria Mirifica’s Study
The enlarge underground tuber accumulate “ phytoestrogens ” (Hormone from Plant) comprising isoflavones (daidzin, daidzein, genistin, genistein and puerarin) and others such as
"miroestrol" & "deoxymiroestol" - "The best & unique phytoestrogens in the world ever found by mankind" and its derivatives, beta-sitosterol, stigmasterol, coumestrol, puerarin, mirificoumestan, kwakhurin and mirificin.

The scope of our study is biotechnology of the White , Red and Black Kwao Krua. Our study has be done by traveling to many forests in many parts of Thailand to search and select for the right and best cultivar of these herbs by rely on botanical characteristic, chemical analysis, consumption history, toxicology test as well as laboratory test and clinical trial.

The result of study under controlled by researcher
According to our research has revealed that Pueraria Mirifica and Butea Superba are safe to be used in human in certain dosage as well as consumption period.

More than 20 kinds of chemical substances were analyzed from Pueraria Mirifica and they were divided in to 3 groups

1. A mild action substances in the group of Sterol.

2. The substances in Isoflavanoid groups which also be found in soybean, a commonly used health nourishment in Japanese food and is proven to be anti-breast cancer.

3. An acute substances of Coumestan group


Our researcher has been conducting a series of researches covering the chemical analysis, tissue culture, mass propagation, cultivar improvement, production, product development and testing and so on for 9 years. Because this finding showed a great impact to the herbal food, cosmetic, drug and beverage industries, so he has submitted patents concerned these findings and application in both Thailand and abroad

The result shows that our selected Pueraria Mirifica cultivar contains very high isoflavone contents and showing high antimutagenic effects as well as high killing effects to human mammary cancer cell line.

Nowadays nutritionists recommend the consumer to consume isoflavone regularly for the purpose of cancer protection normally found on post-menopausal and people who are Hormone Imbalance.

What is benefit of Miroestrol and its derivatives?
Miroestrol and its derivatives are also precious chemicals in the White Kwao Krua which promote estrogenic and mammogenic effects to various tissues as Breast Enlargement or Breast Tissue Reformation.
( See the result of Clinical study about Breast Enlargement by Pueraria mirifca herbal and FAQ Breast Enlargement Forum ) and organs such as uterus, ovary and skin as HRT (Hormone Replacement Therapy)

What is different between Soya and Pueraria Mirifica ?
Soya, the main oriental food and Alfalfa, the western health food products contains lower amount of phytoestrogens especially there is no miroestrol and its derivatives. Their benefit to the body is far less than that of Pueraria mirifica. The researches confirm that these chemicals are potent anti-breast cancer , anti-prostate hyperplasia, anti-colon cancer, anti-osteoporosis and also anti-cardiovascular disease via the potent reduction of blood cholesterol and also anti-menopausal syndrome.

Further information about : Chemical Composition and Hormone Replacement Therapy
Published by : Medicinal Plant Research Institute, Department of Medical Sciences, Ministry of Public Health, Thailand , July 2000

Efficacy and safety of Pueraria mirifica (Kwao Kruea Khao) for the treatment of  vasomotor symptoms in pre-menopausal women: Phase II Study.

J Med Assoc Thai.  2004 Jan;87(1):33-40.   Lamlertkittikul S, Chandeying V.

 Department of Obstetrics and Gynecology, Hat Yai Regional Hospital, Songkhla  90110, Thailand.

OBJECTIVES: To evaluate the preliminary efficacy and safety of Pueraria mirifica in the treatment of vasomotor symptoms. DESIGN: Open-label study. SETTING: Hat Yai Regional Hospital, Thailand. SUBJECTS: Pre and postmenopausal women with vasomotor symptoms, such as hot flushes and night sweats. Other unpleasant symptoms, urogenital and psychological symptoms, were also evaluated.

MATERIAL AND METHOD: Patients were enrolled voluntarily and randomly received 50 mg or 100 mg of Pueraria mirifica in capsules, once daily for six months.

RESULTS: Of the 48 enrolled patients, 11 cases were excluded for failing to complete the initial work-up. Thirty-seven cases were evaluated. 20 of 37 (54.1%) randomly received a dose of 50 mg/day of Pueraria mirifica (Group A), and 17 of 37 (45.9%) received 100 mg/day of Pueraria mirifica (Group B). The mean of the modified Greene climacteric scale decreased from 35.6 to 26.6, 17.2 and 15.1 in group A, while group B, declined from 32.6 to 21.0, 14.8 and 13.6 at 1-, 3- and 6-month respectively. The mean serum estradiol, fluctuated from the baseline of 76.6 to 55.4, 56.7, 72.5, 69.2, 114.2 and 74.5 pg/ml at 1-, 2-, 3-, 4-, 5- and 6-month respectively. Whereas the mean serum follicle-stimulating hormone (FSH)/luteinizing hormone (LH) was stable in the range of; 27.1/12.6, 28.3/12.9and 22.5/11.4 mIU/ml at baseline, 3- and 6-month respectively.

CONCLUSIONS: Pueraria mirifica, containing phytoestrogens, relatively alleviated the climacteric symptoms in perimenopausal women. The transient negative profiles occurred in a small number of subjects that included anemia, and liver profiles.  While there was a slight decrease in lipoproteins and an increase in hormonal profiles, Pueraria mirifica demonstrates great promise in the treatment of climacteric symptoms among perimenopausal women. However, optimal doses should be clinically assessed, to meet appropriate individual responses.

 

Chulalongkorn University

 

Conclusion of Clinical Study (pre-menopausal women)
Pre-menopausal women
Function: (Food Supplement)    
Test Period:      2 months
Number of subjects:  31 Placebo
test group 1. 2 200 mg capsule/ day    15 days/month
test group 2  4 200 mg capsules           15 days/month

This test group showed significant change with different number in all recorded parameters, including, including mammary pain (44%) which is related to breast firmness and may relate to breast enlargement, nicer skin(88%), healthier hair(75%),charisma clearance(100%), increase vaginal secretion(44%),breast enlargement(90%), and hip enlargement(9%).

The second tested group contains 34 subjects, received 200 mg Pueraria mirifica filled capsule to consume 4 capsules/day in the same condition as the placebo group.  This group showed significant change with higher numbers in all recorded parameters, including mammary pain (94%), skin recovery (94%), healthier hair (88%), charisma clearance (100%), increased vaginal secretion (85%), and thus could restore female potency in some subjects, healthier menstruation, (29%), breast firmness (94%), breast enlargement (88%), and hip enlargement (59%). Some subjects claimed that the high blood cholesterol levels also decreased.

Conclusion : Pueraria Mirifica enhanced breast size and firmness

         source:  Copyright © 2002 [Americanphytolab.netfirms]. All rights reserved. Revised: 02/09//2005

Pueraria Mirifica contains different types of Phytoestrogens, which may be broadly classified into thress main groups:

1. Chromene group : The Miroestrol and Deoxymiroestrol, these are comparatively  potent Phytoestrogens Unique to Pueraria Mirifica, their structural configuration is very close to the structural configuration of Estradiol-17B.

2. Isoflavonoid group : which comprises of Daidzin and Daidzein, Genistin and Genistein, also Puerarin.

3. The Coumestan group comprising cousmetrol.

This wide variety of  Pytoestrogenic compounds belonging to different groups and present side by side in a single plant, is what make Pueraria Mirifica a very appreciated herb for replacing the decline in the natural hormones in women over 45 years of age or  insufficient of estrogen below 45 years age.

Taking estrogenic hormones (synthetic hormones), has been proven to be carcinogenic. On the other hand, taking Phytoestrogens proved to be anti-carcinogenic or at least delay carcinogenic manifestations. A considerable amount of data has accumulated proving that Phytoestrogens exhibits an inhibitory effect against mammary tumorigenesis, prostate-related cancer and bladder cancer.

Phytoestrogens also exhibit favorable effects other than the dramatic results of protection against certain types of cancer. In other words, as result of the decrease in the level of estrogenic hormones, the body's systems and their function begin to decelerate and the immune system weakens, accordingly menopausal women will usually experience both psychological and physiological changes. Psychological changes ranges from anxiety, tension and nervousness to chronic depression, whereas the physiological changes include hot flushes, fatigue and insomnia to more severe conditions as bone loss, balding and degeneration of the reproductive area.

The health benefits of Phytoestrogens from Pueraria Mirifica is at least 2 folds:

First they can bind to the estrogen receptors with respective degrees of affinity. Hence unique phytoestrogens from Pueraria Mirifica can correct estrogen insufficient in the body and relieve any resulting symptoms.

Secondly, there is evidence to support that phytoestrogen consumption contributes to lower risks of cardiovascular diseases. Soy bean, which contains similar isoflavonoids as those found in Pueraria Mirifica, was proven to decrease the level of LDL, Cholestrol and increase the level of HDL in the blood.

The following safety Studies were conducted:

Mutagenicity Assay: Ames test showed no sign of Mutagenicity for Pueraria Mirifica.

LD-50: The LD-50 of Pueraria Mirifica in mice was found to be greater than 16g/kg of the body weight. Since the normal therapeutic dose has been estimated to be 0.8-1.3 mg/kg/day, it is quite obvious that the safety margin is very high. [ Chivapat, S., Chavalittumrong, P., Rattanajarasroj, S., Chuthaputti, A. and Panyamang, S., Bull. Dept, Med, Sciences, 42, 202 (2000) ]

Human Studies: Three female human studies, two in Thailand and one in Japan, were conducted, no significant signs of toxicity or adverse effects could be reported by the investigators. [ Chandeying, V., Kuramoshi, T. and Schauss, A., Personal Communication (2001) ]

Skin Tests: With regards to the safety and efficacy of dermal preparations of Pueraria Mirifica extract, standard dermal toxicity tests were performed in various animal species as well as in human and no toxicity was observed. Moreover, the efficacy of breast creams has been recently evaluated in a large group of human volanteers. [ Thailand Institute of Scientific and Technological Research (July 2002) ]

Various forms and preparations of Pueraria Mirifica should provide an effective, safe and inexpensive alternative to women who wish to take charge of their own health and to enhance their beauty or utilize Pueraria Mirifica for various cosmetic purposes.

When applied to the skin Pueraria Mirifica will be beneficial to that respective part of the body. Topical uses of Pueraria Mirifica have been known to include:

 

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The Introduction & History of  Pueraria Mirifica A Shaw et Suvatabhandu 

( "The World Only Miracle Herb that has the Best & Unique Phytoestrogen: Miroestrol & Deoxymiroestrol") 

 

For more than 500 years, people in South East Asia have been using the root of "White Kwao Krua" for its profound Anti-Aging properties. This root has been identified as Pueraria Mirifica Airy Shaw et Suvat (scientific name), which belongs to family Papilionaceae (Leguminosae).

 

Folklore goes on to say that the root is a "Fountain of Youth" for aged women and men. It serves as anti-wrinkle agent for aged and wrinkled skin, darkens white hair and increases hair growth, alleviates cataract problems, helps with memory loss, increase energy and vigor, blood circulation,

improve appetite and sleep disorders.

 

The name "Mirifica"  in Latin means Miracle. There are more than 13 related, identified species of  Pueraria with similar tuberous roots they can be differentiated by the taxonomical characteristics of leaf, flower, inflorescence, fruit and covering trichomes. 

 

There  are  13  "Different Species"  of  Pueraria‘s  Family in Thailand :

* But only "Botanical  Pueraria Mirifica has the "Unique Phytoestrogen:  Deoxymiroestrol & Miroestrol " which posses the highest estrogenic activity among the known  phyto-estrogens due to "molecule structural similarity to estradiol". *

Types of Pueraria

Does it contain of  Miroestrol & Deoxymiroestrol, the miracle phytoestrogen ?

1)  Pueraria Mirifica A Shaw et Suvatabhandu P YES, and it's THE ONLY PLANT in The World contain Miroestrol & Deoxymiroestrol
2)   Pueraria Alopecuroides Craib X NO
3)   Pueraria Candollei Graph. Ex. Benth X NO
4)   Pueraria Imbricata Van der Maesen sp. Nov. X NO
5)   Pueraria Lobata X NO
6)   Pueraria Lobata Var. Montana X NO
7)   Pueraria Lobata Var. Thomsoni X NO
8)   Pueraria Var. Phaseoloides X NO
9)   Pueraria Var. Javanica X NO
10) Pueraria Var. Subspicata X NO
11) Pueraria Wallichii X NO
12) Pueraria Rigens X NO
13) Pueraria Stricta X NO

 

But, the only species with distinct estrogenic activity was found to be Pueraria Mirifica Airy Shaw et Suvat. (herein after "Pueraria Mirifica"),even the taxonomically close species Pueraria Candollei Graph Ex Benth does not contain any measurable amount of Miroestrol & Deoxymiroestrol (with have highest estrogenic activity among the known phytoestrogens in the world), and Pueraria Candollei also has lesser amount of isoflavonoids.

 

For best results the location, age of plant (2-4 years), atmospheric conditions(no rain), drying process and storage conditions are carefully monitored.

 

Local communities in Thailand have used Pueraria Mirifica for well over 100 years, specifically for its rejuvenating qualities. They belief in the rejuvenating properties of Pueraria Mirifica has been passing down from one generation to another and more recently through the publication by Luang Anusan Suntara (1931). In these writing it is mentioned that the use of this root, will make the skin smooth like a six year old child and allow you to live 1,000 years and prevent suffering from parasites, while also enhancing memory.

 

In May 1931, Luang Anusan Suntara published a pamphlet on the subject of "Kwao Krua" describing different ways of preparing folk medicine using Pueraria Mirifica and the claims of its rejuvenating power. It is stated in the pamphlet that Pueraria Mirifica can:
1) Serve as an anti-wrinkle agent for aged and wrinkled skin
2) Darken white hair, and increase hair growth
3) Alleviated cataract problems
4) Help with memory loss
5) Increase energy and vigor, more reflexive bodily movements
6) Increase blood circulation
7) Have appropriate appetite

8) Alleviate sleep disorders

 

In 1932, Dr. A.F.G. Kerr, the Director of the Botanical Section of the Journal of the Siam Society, directed the attention of the scientific community to the fact that the tuberous roots of a Thai plant called "Kwao Krua", mistakenly identified then as Butea Superba, were considered to be of value as a rejuvenating drug.  Dr. Kerr was the first to create international awareness of the rejuvenating qualities of this plant, which subsequently led to the isolation of a potent phyto-estrogen that is unique to this plant only and to the identification of the plant as Pueraria Mirifica in 1952.

Serves as the Fountain of Youth for aged women and men.

                     
Source: Medicinal Plant Research Institute, Department of Medical Sciences, Ministry of Public Health, Thailand; July 2000

 

 

 

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